THE IMPACT OF SOME XENOESTROGENS ON MAMMALIAN MALE REPRODUCTIVE SYSTEM
Xenoestrogens are exogenous group of compounds, which own heterogenous chemical structure. Th ey may interact with endocrine system and mimic the action of natural hormones as well as may act as antiandrogens. Widespread exposure to xenostrogens, which enter to composition of many articles of general applications, is considered one of reason reduced sperm volume and diminished sperm quality, and may lead to infertility as well as contribute for increased frequency of congenital defects of male genitals. Current paper describes the eff ects of benzylbutyl phthalate (BBP), di -n -butyl phthalate (DBP), di(2 -ethylhexyl)phthalate (DEHP), nonylphenol (NP) and bisphenol A (BPA). All above xenoestrogens cause diminished sperm count, increased frequency of abnormal spermatozoa and DNA damage in mammals, especially following long exposure and after starting of exposure before achievement of sexual maturity. Changes induced in male gametes may cause mutations leading to increased pre - and postnatal mortality of the off spring and to incidence of congenital malformations, growth retardation, delay in sexual development, disturbances in sex ratio and diminished quality of semen in F1 generation. So, limitation of contact with xenoestrogens of adult and particularly of children is recommended.